FLUXMATERIA — INVERSE SEARCH

Stop searching. Start specifying.

Define what you need — property ranges, constraints, tradeoffs. FluxMateria finds candidates that match and explains why others were rejected.

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Capabilities

📐

Multi-property constraints

Define targets, ranges, and hard constraints across multiple properties

📊

Candidate ranking

Results ranked against your spec

📈

Pareto visualization

See tradeoff frontiers when properties conflict

📝

Rejection logging

Know exactly why candidates didn't make the cut

🔄

Iterative refinement

Adjust spec based on what's achievable

📤

Decision rationale

Export shortlists with full reasoning

How it works

Traditional screening

Input: large compound library. Output: ranked list requiring manual filtering.

Screen everything, then apply filters. Resources spent evaluating unsuitable candidates.

Inverse Search

Input: property constraints (logP 1-3, MW <500, no PAINS, acceptable hERG). Output: matching candidates.

Define success criteria first. FluxMateria identifies candidates that satisfy constraints.

Tradeoff visibility

Real discovery involves tradeoffs. Inverse Search shows:

Full matches

Which candidates meet all constraints

~
Near matches

Which candidates meet most constraints (and which they miss)

📈
Pareto frontiers

When properties conflict, see the tradeoff space

💡
Relaxation analysis

What you'd gain by relaxing specific constraints

Workflow

1

Define spec

Set property targets, ranges, and hard constraints

2

Search

FluxMateria evaluates candidate space

3

Review

Ranked results with constraint satisfaction

4

Refine

Adjust spec based on what's achievable

5

Compare

Analyze Pareto frontiers and tradeoffs

6

Export

Shortlist with decision rationale

Use cases

Lead optimization

Set target ranges for potency, selectivity, and ADMET properties. Find candidates that hit multiple criteria simultaneously.

Materials screening

Define band gap range, thermal stability threshold, and cost constraints. Get ranked compositions that meet your spec.

Formulation development

Specify solubility requirements, stability windows, and excipient compatibility. See what's achievable in your target space.

Research planning

Before synthesis, understand the tradeoff landscape. Know which constraints are limiting before you start.

🎯

Currently in Beta

Inverse Search is available to beta partners. We're expanding property coverage and refining the tradeoff analysis based on real-world use.

Beta includes:

  • Multi-property constraint definition
  • Ranked candidate output with satisfaction scores
  • Rejection logging with reasons
  • Basic Pareto visualization
  • Advanced relaxation analysis (coming soon)
  • Custom property integration (coming soon)

Evaluate Inverse Search

View the walkthrough

See the full workflow: define constraints, review ranked results, analyze tradeoffs, export decisions.

View Demo →

Join the beta

Bring your constraints. We'll help you explore the tradeoff space and find what's achievable.

Request Beta Access →